An experimental investigation of the effects of chronic stress on bone-to-implant contact
Dundar Serkan, Bozoglan Alihan, Yaman Ferhan, Kirtay Mustafa, Bulmus Ozgur, Aydinyurt Hacer Sahin, Solmaz Murat Yavuz, Yanen Cenk,
소속 상세정보
( Dundar Serkan ) - Firat University Faculty of Dentistry Department of Periodontology
( Bozoglan Alihan ) - Firat University Faculty of Dentistry Department of Periodontology
( Yaman Ferhan ) - Private practice
( Kirtay Mustafa ) - Private practice
( Bulmus Ozgur ) - Firat University Faculty of Medicine Department of Physiology
( Aydinyurt Hacer Sahin ) - Yuzuncu Yil University Faculty of Dentistry Department of Periodontology
( Solmaz Murat Yavuz ) - Firat University Faculty of Engineering Department of Mechanical Engineering
( Yanen Cenk ) - Firat University Faculty of Engineering Department of Mechanical Engineering
Abstract
Objectives: This study aimed to investigate the effects of chronic restraint stress on the osseointegration of titanium implants.
Materials and Methods: Twenty adult male Wistar albino rats were used in the study. After surgical insertion of titanium implants into the metaphyseal part of the tibial bone, rats were randomly divided into two groups: a control group (CNT group) and an experimental restraint stress group (RS group). In the CNT group, titanium implants were inserted surgically, and rats received no further treatment during the 47-day experimental period. In the RS group, restraint stress was applied for 3 hours per day for 45 days, beginning 2 days after implant surgery. Weight of the rats was measured prior to surgery and at the end of the study to analyze the effects of stress. At the end of the experimental period, rats were euthanized, and implants and surrounding bone tissues were used for undecalcified histological analysis. Serum cortisol levels were assessed in cardiac blood samples from the rats following centrifugation.
Results: Average weight of rats in the RS group was lower than that of rats in the CNT group after the experimental protocol had been completed (P<0.05). Further, serum cortisol levels were higher in the RS group than in the CNT group (P<0.05). There were no significant differences in bone-implant connection levels between the two groups (P>0.05).
Conclusion: The data analyzed in this study suggest that chronic restraint stress did not adversely affect rats during a 45-day osseointegration period.
키워드
Restraint stress; Osseointegration; Bone-to-implant contact; Rats; Tibia
원문 및 링크아웃 정보
등재저널 정보